3,4,5-trihydroxycinnamic acid decyl ester
3,4,5-Trihydroxycinnamic acid decyl ester
CAS: 1770778-45-4
Molecular Formula: C19H28O5
3,4,5-trihydroxycinnamic acid decyl ester - Names and Identifiers
| Name | 3,4,5-Trihydroxycinnamic acid decyl ester |
| Synonyms | 3,4,5-Trihydroxycinnamic acid decyl ester 2-Propenoic acid, 3-(3,4,5-trihydroxyphenyl)-, decyl ester, (2E)- |
| CAS | 1770778-45-4 |
3,4,5-trihydroxycinnamic acid decyl ester - Physico-chemical Properties
| Molecular Formula | C19H28O5 |
| Molar Mass | 336.42 |
| Density | 1.143±0.06 g/cm3(Predicted) |
| Boling Point | 514.2±50.0 °C(Predicted) |
| pKa | 8.82±0.15(Predicted) |
| Storage Condition | 2-8°C，干燥，密封 |
| In vitro study | 3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro. 3,4,5-Trihydroxycinnamic acid decyl ester (0.1-40 μM) inhibits pancreatic lipase activity in dose-dependent manner, with an EC 50 value being approximately 0.9 μM. 3,4,5-Trihydroxycinnamic acid decyl ester inhibits pancreatic lipase in vitro and lipid accumulation during 3T3-L1 cell differentiation. |
| In vivo study | 3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oil orally. Animal Model: 6 weeks old Male ddY mice Dosage: 30 mg/kg, 150 mg/kg Administration: Oral administration Result: Reduced plasma TG in a dose-dependent manner. |
3,4,5-trihydroxycinnamic acid decyl ester - Reference Information
| biological activity | 3,4,5-Trihydroxycinnamic acid decyl ester is a highly effective lipid absorption and accumulation inhibitor with anti-obesity effect. The 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase (pancreatic lipase) inhibitor with an EC50 of approximately 0.9 μM. |
| target | EC50: 0.9 μM (pancreatic lipase) |
| in vitro study | 3,4, 5-Trihydroxyamino acid decyl ester (30 μ m) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro.3, 4, 5-Trihydroxyamino acid decyl ester (0.1-40 μ m) inhibits pancreatic lipase activity in pose-dependent manner, with an EC 50 value being approximately 0.9 μM. 3,4, 5-Trihydroxyamino acid decyl ester inhibits pancreatic lipase in Vitro and Lipid accumulation during 3T3-L1 cell differentiation. |
| in vivo study | 3,4, 5-Trihydroxyamino acid decyl ester (30-150 mg/kg; P. o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oilorally. Animal model: 6 weeks old male ddy mice dosage: 30 mg/kg, 150 mg/kg Administration: oral administration Result: Reduced plasma TG in a dose-dependent manner. |
| Animal Model: | 6 weeks old Male ddY mice |
| Dosage: | 30 mg/kg, 150 mg/kg |
| Administration: | Oral administration |
| Result: | Reduced plasma TG in a dose-dependent manner. |
Last Update：2024-04-09 15:16:42
